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Ohio State vs USC Prediction & Odds

Quick answer
  • Ohio State at USC: kickoff Saturday, October 31, 2026 at 7:30 PM ET.
  • Spread: Ohio State -7, the median of 4 sportsbooks. Best available: Ohio State -7 (-105, Fanatics) · USC +7 (-115, Fanatics).
  • Total (over/under): 52.5. Best available: Over 52.5 (-110, DraftKings) · Under 52.5 (-110, DraftKings).
  • Best moneyline: Ohio State (-245, Fanatics) · USC (+205, DraftKings).
  • Lines as of Sun, Oct 25 · 2:01 AM ET; they move after that.

Ohio State vs USC odds

Best available moneyline, spread and total across 4 sportsbooks. Every book is one tap away.

2:01 AM ET
4 booksMoneylineSpreadTotal
Ohio State -245 Fanatics -7.0 -105 Fanatics O 52.5 -110 DraftKings
USC +205 DraftKings +7.0 -115 Fanatics U 52.5 -110 DraftKings
View all sportsbooks (4)Eligible fresh comparisons
BookMoneylineSpreadTotal
BetR Sportsbook -256+195 —— ——
DraftKings -250+205 —— O 52.5 -110U 52.5 -110
Fanatics -245+200 -7.0 -105+7.0 -115 O 52.5 -110U 52.5 -110
PointsBet -250+200 —— ——

◆ Best: the most favorable fresh line, then price, for that exact side. Rows read Ohio State first, then USC.

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Ohio State vs USC AI prediction

The KarmaEdge AI spread and total projections next to the posted line, with the KarmaEdge AI Score.

No KarmaEdge AI projection is published for this game yetGames appear once the KarmaEdge AI model is published for the slate. Nothing is filled in meanwhile.

All College football AI predictions →

Ohio State vs USC line movement

DraftKings lines from the open (or the first line KarmaEdge tracked) to now.

MarketSideOpen / first trackedNowMove
MoneylineOhio State -298.0 Open -250.0 +48
MoneylineUSC 240.0 Open 205.0 -35
TotalOver 54.5 Open 52.5 -2
TotalUnder 54.5 Open 52.5 -2

Every College football line move on Live Trends →

Frequently asked questions

What time is Ohio State vs USC?

Kickoff is Saturday, October 31, 2026 at 7:30 PM ET.

What is the spread for Ohio State vs USC?

The median spread across 4 sportsbooks is Ohio State -7 as of Sun, Oct 25 · 2:01 AM ET. Best available by side: Ohio State -7 (-105, Fanatics) · USC +7 (-115, Fanatics).

What is the over/under for Ohio State vs USC?

The median total across 4 sportsbooks is 52.5. Best available: Over 52.5 (-110, DraftKings) · Under 52.5 (-110, DraftKings).

What are the moneyline odds for Ohio State vs USC?

The best available moneylines are Ohio State (-245, Fanatics) · USC (+205, DraftKings).

Does KarmaEdge have an AI prediction for Ohio State vs USC?

Not yet. No KarmaEdge AI projection is published for Ohio State vs USC; games appear once the model is published for the slate. Nothing is filled in meanwhile.

Is KarmaEdge.AI a sportsbook?

No. KarmaEdge.AI is not a sportsbook and never accepts wagers. It is a research site that compares markets and shows KarmaEdge AI research next to them.

KarmaEdge.AI is not a sportsbook and never accepts wagers. Lines move; each shows when it was read. Projections are research, not guarantees. 18+ and of legal age where you are. Gambling problem? Call 1-800-GAMBLER.