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Washington Commanders vs San Francisco 49ers Prediction & Odds

Monday, October 19, 2026 at 8:15 PM ET · Levi's Stadium

Quick answer

Washington Commanders at San Francisco 49ers: kickoff Monday, October 19, 2026 at 8:15 PM ET, Levi's Stadium.
Spread: 49ers -7.5, the median of 15 sportsbooks. Best available: Commanders +7.5 (-108, Tipico) · 49ers -7.5 (+100, ESPN BET).
Total (over/under): 51.5. Best available: Over 51.5 (-109, Bally Bet) · Under 52.5 (-115, Tipico).
Best moneyline: Commanders (+345, Circa) · 49ers (-395, DraftKings).
Lines as of Mon, Oct 19 · 1:48 PM ET; they move after that.

Commanders vs 49ers odds

Best available moneyline, spread and total across 15 sportsbooks. Every book is one tap away.

Mon, Oct 19 · 8:15 PM ET 1:48 PM ET

15 booksMoneylineSpreadTotal

Washington Commanders +345 Circa +7.5 -108 Tipico O 51.5 -109 Bally Bet

San Francisco 49ers -395 DraftKings -7.5 +100 ESPN BET U 52.5 -115 Tipico

View all sportsbooks (15)Eligible fresh comparisons

BookMoneylineSpreadTotal

Bally Bet1:48 PM ET +320-420 +7.5 -115-7.5 -106 O 51.5 -109U 51.5 -112

BetMGM1:47 PM ET +320-425 +7.5 -115-7.5 -105 O 52.0 -108U 52.0 -110

BetR Sportsbook1:46 PM ET +310-417 —— ——

BetRivers1:48 PM ET +320-420 +7.5 -115-7.5 -106 O 51.5 -109U 51.5 -112

Caesars1:46 PM ET +320-420 +7.5 -110-7.5 -109 O 51.5 -109U 51.5 -110

Circa1:45 PM ET +345-425 +7.5 -115-7.5 -105 O 52.0 -110U 52.0 -110

DraftKings1:45 PM ET +310-395 +7.5 -112-7.5 -108 O 51.5 -115U 51.5 -105

ESPN BET1:46 PM ET +320-425 +7.5 -120-7.5 +100 O 51.5 -110U 51.5 -110

Fanatics1:48 PM ET +325-425 +7.5 -115-7.5 -105 O 51.5 -110U 51.5 -110

FanDuel1:46 PM ET +315-400 +7.5 -120-7.5 -102 O 51.5 -112U 51.5 -108

Hard Rock Bet1:48 PM ET +325-425 +7.5 -110-7.5 -110 O 51.5 -110U 51.5 -110

PointsBet1:46 PM ET +330-417 +7.5 -115-7.5 -105 O 51.5 -111U 51.5 -111

SugarHouse1:47 PM ET +320-420 +7.5 -115-7.5 -106 O 51.5 -109U 51.5 -112

theScore Bet1:47 PM ET +320-425 +7.5 -120-7.5 +100 O 51.5 -110U 51.5 -110

Tipico1:45 PM ET +310-455 +7.5 -108-7.5 -118 O 52.5 -111U 52.5 -115

◆ Best: the most favorable fresh line, then price, for that exact side. Rows read Washington Commanders first, then San Francisco 49ers.

Compare every NFL game on Live Odds →

Commanders vs 49ers AI prediction

The KarmaEdge AI spread and total projections next to the posted line, with the KarmaEdge AI Score.

NFL

Washington CommandersWAS · Away

—

San Francisco 49ersSF · Home

—

KarmaEdge AI Score 34

★★

Posted line+7.5

KarmaEdge AI projectionSan Francisco 49ers -6.5

Projection versus posted line+1.0 points

Compare eligible sportsbooks 14

DraftKingsAway +7.5 -112Home -7.5 -108

Bally BetAway +7.5 -115Home -7.5 -106

BetMGMAway +7.5 -115Home -7.5 -105

BetRiversAway +7.5 -115Home -7.5 -106

CaesarsAway +7.5 -110Home -7.5 -109

CircaAway +7.5 -115Home -7.5 -105

ESPN BETAway +7.5 -120Home -7.5 +100

FanaticsAway +7.5 -115Home -7.5 -105

FanDuelAway +7.5 -120Home -7.5 -102

Hard Rock BetAway +7.5 -110Home -7.5 -110

PointsBetAway +7.5 -115Home -7.5 -105

SugarHouseAway +7.5 -115Home -7.5 -106

theScore BetAway +7.5 -120Home -7.5 +100

TipicoAway +7.5 -108Home -7.5 -118

Why the projection differs

Independent game-model projection compared with a current sportsbook line.

How this score works

NFL

Washington CommandersWAS · Away

—

San Francisco 49ersSF · Home

—

KarmaEdge AI Score 42

★★

Posted line+51.5

KarmaEdge AI projection52.1

Projection versus posted line+0.6 points

Compare eligible sportsbooks 14

DraftKingsTotal 51.5Over -115 · Under -105

Bally BetTotal 51.5Over -109 · Under -112

BetMGMTotal 52Over -108 · Under -110

BetRiversTotal 51.5Over -109 · Under -112

CaesarsTotal 51.5Over -109 · Under -110

CircaTotal 52Over -110 · Under -110

ESPN BETTotal 51.5Over -110 · Under -110

FanaticsTotal 51.5Over -110 · Under -110

FanDuelTotal 51.5Over -112 · Under -108

Hard Rock BetTotal 51.5Over -110 · Under -110

PointsBetTotal 51.5Over -111 · Under -111

SugarHouseTotal 51.5Over -109 · Under -112

theScore BetTotal 51.5Over -110 · Under -110

TipicoTotal 52.5Over -111 · Under -115

Why the projection differs

Independent game-model projection compared with a current sportsbook line.

How this score works

All NFL AI predictions →

Commanders vs 49ers line movement

DraftKings lines from the open (or the first line KarmaEdge tracked) to now.

Market	Side	Open / first tracked	Now	Move
Moneyline	Commanders	205.0 Open	310.0	+105
Moneyline	49ers	-250.0 Open	-395.0	-145
Spread	Commanders	5.5 Open	7.5	+2
Spread	49ers	-5.5 Open	-7.5	-2
Total	Over	50.5 Open	51.5	+1
Total	Under	50.5 Open	51.5	+1

Every NFL line move on Live Trends →

Commanders vs 49ers player props

Current prop lines for this game: 12 of 26. Free line comparison; no picks or guarantees.

Jayden DanielsQB · WAS Passing Yards 210.5 Best over 210.5 -110 · Fanatics
Best under 210.5 -110 · Circa
Brock PurdyQB · SF Passing Yards 250.5 Best over 250.5 -110 · Fanatics
Best under 250.5 -112 · Caesars
Jayden DanielsQB · WAS Rushing Yards 38.5 Best over 38.5 -113 · FanDuel
Best under 38.5 -113 · Caesars
Brock PurdyQB · SF Rushing Yards 19.5 Best over 19.5 -105 · ESPN BET
Best under 19.5 -110 · Circa
Christian McCaffreyRB · SF Rushing Yards 61.5 Best over 61.5 -113 · FanDuel
Best under 61.5 -110 · DraftKings
Rachaad WhiteRB · WAS Rushing Yards 44.5 Best over 44.5 -110 · ESPN BET
Best under 44.5 -109 · DraftKings
Chig OkonkwoTE · WAS Receiving Yards 24.5 Best over 24.5 -107 · Caesars
Best under 24.5 -110 · Circa
George KittleTE · SF Receiving Yards 66.5 Best over 66.5 -113 · FanDuel
Best under 66.5 -111 · Caesars
Christian McCaffreyRB · SF Receiving Yards 39.5 Best over 39.5 -113 · FanDuel
Best under 39.5 -110 · DraftKings
Mike EvansWR · SF Receiving Yards 64.5 Best over 64.5 -105 · Caesars
Best under 64.5 -125 · ESPN BET
Rachaad WhiteRB · WAS Receiving Yards 13.5 Best over 13.5 -112 · DraftKings
Best under 13.5 -108 · Caesars
Terry McLaurinWR · WAS Receiving Yards 49.5 Best over 49.5 -110 · ESPN BET
Best under 49.5 -110 · Circa

All Commanders vs 49ers player props →

Frequently asked questions

What time is Commanders vs 49ers?

Kickoff is Monday, October 19, 2026 at 8:15 PM ET at Levi's Stadium.

What is the spread for Commanders vs 49ers?

The median spread across 15 sportsbooks is 49ers -7.5 as of Mon, Oct 19 · 1:48 PM ET. Best available by side: Commanders +7.5 (-108, Tipico) · 49ers -7.5 (+100, ESPN BET).

What is the over/under for Commanders vs 49ers?

The median total across 15 sportsbooks is 51.5. Best available: Over 51.5 (-109, Bally Bet) · Under 52.5 (-115, Tipico).

What are the moneyline odds for Commanders vs 49ers?

The best available moneylines are Commanders (+345, Circa) · 49ers (-395, DraftKings).

Does KarmaEdge have an AI prediction for Commanders vs 49ers?

KarmaEdge AI projects on the spread, San Francisco 49ers -6.5 against DraftKings 7.5; on the total, 52.08 against DraftKings 51.5. Projections are research, not guarantees.

Is KarmaEdge.AI a sportsbook?

No. KarmaEdge.AI is not a sportsbook and never accepts wagers. It is a research site that compares markets and shows KarmaEdge AI research next to them.

KarmaEdge.AI is not a sportsbook and never accepts wagers. Lines move; each shows when it was read. Projections are research, not guarantees. 18+ and of legal age where you are. Gambling problem? Call 1-800-GAMBLER.