San Francisco 49ers vs Dallas Cowboys Prediction & Odds
· AT&T Stadium
49ers vs Cowboys AI prediction
The KarmaEdge AI spread and total projections next to the posted line, with the KarmaEdge AI Score.
49ers vs Cowboys odds
Best available moneyline, spread and total across 15 sportsbooks. Every book is one tap away.
San Francisco 49ers
-210
Circa
-4.0 -108
BetMGM
O 55.0 -110
Bally Bet
Dallas Cowboys
+185
DraftKings
+4.5 -105
Tipico
U 56.5 -110
Hard Rock Bet
View all sportsbooks (15)Eligible fresh comparisons
Bally Bet
-220+175
-4.5 -107+4.5 -114
O 55.0 -110U 55.0 -110
BetMGM
-220+180
-4.0 -108+4.0 -110
O 55.5 -110U 55.5 -108
BetR Sportsbook
-227+180
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BetRivers
-220+175
-4.5 -107+4.5 -114
O 55.0 -110U 55.0 -110
Caesars
-218+183
-4.5 -106+4.5 -114
O 55.5 -110U 55.5 -110
Circa
-210+180
-4.0 -110+4.0 -110
O 55.5 -110U 55.5 -110
DraftKings
-225+185
-4.5 -105+4.5 -115
O 55.5 -110U 55.5 -110
ESPN BET
-215+180
-4.0 -110+4.0 -110
O 55.5 -110U 55.5 -110
Fanatics
-220+180
-4.0 -110+4.0 -110
O 56.0 -110U 56.0 -110
FanDuel
-215+180
-4.5 +100+4.5 -120
O 55.5 -115U 55.5 -105
Hard Rock Bet
-220+185
-4.0 -115+4.0 -110
O 56.5 -110U 56.5 -110
PointsBet
-227+185
-4.5 -111+4.5 -111
O 55.5 -111U 55.5 -111
theScore Bet
-213+180
-4.0 -110+4.0 -110
O 55.5 -110U 55.5 -110
◆ Best: the most favorable fresh line, then price, for that exact side. Rows read San Francisco 49ers first, then Dallas Cowboys.
49ers vs Cowboys line movement & betting splits
DraftKings lines from the open (or the first line KarmaEdge tracked) to now. Bet % and Money % appear only where verified splits are available.
| Market | Side | Open / first tracked | Now | Move | Bet % | Money % |
|---|---|---|---|---|---|---|
| Moneyline | 49ers | 100.0 Open | -225.0 | +100 → -225 | 91% | 95% |
| Moneyline | Cowboys | -120.0 Open | 185.0 | -120 → +185 | 9% | 5% |
| Spread | 49ers | 1.5 Open | -4.5 | -6 | 100% | 100% |
| Spread | Cowboys | -1.5 Open | 4.5 | +6 | 0% | 0% |
| Total | Over | 52.5 Open | 55.5 | +3 | 50% | 99% |
| Total | Under | 52.5 Open | 55.5 | +3 | 50% | 1% |
49ers vs Cowboys on the field
Each team's listed starters in its base formation, from the depth charts as of Nov 8, 2026. Tap a player for the backups.
Cowboys defense · Base 3-4
- #99 LT Overton
- #90 Jonathan Bullard Q
- #93 Elijah Garcia
- #94 Kelvin Gilliam Jr.
- #40 Von Miller
- #41 James Houston
- #55 Jaishawn Barham
- #50 Shemar James
- #45 Justin Barron
- #35 Marist Liufau Q
- #59 Tyrus Wheat
- #57 Malachi Lawrence O
- #2 Cobie Durant
- #29 Devin Moore
- #14 Markquese Bell
- #34 Jalen Thompson
- #11 Alijah Clark
- #43 Juanyeh Thomas
- #23 Ameer Speed
- #28 Shavon Revel Jr.
- #10 Mac Jones
- #14 Kurtis Rourke
- #26 Kaelon Black
- #29 Jordan James
- #31 Isaac Guerendo
- #17 Jordan Watkins
- #86 KhaDarel Hodge
- #1 Ricky Pearsall
- #84 Brandin Cooks
- #3 Christian Kirk O
- Brandon Aiyuk
- #4 Jacob Cowing
- #7 De'Zhaun Stribling
- #89 Luke Farrell
- #9 Brayden Willis
- #88 Jake Tonges
- #76 Vederian Lowe
- #69 Enrique Cruz Jr.
- #62 Austen Pleasants
- #74 Carver Willis
- #63 Nick Zakelj
- #58 Jarrett Patterson
- #74 Carver Willis
- #69 Enrique Cruz Jr.
49ers offense · 11 personnel
49ers defense · Base 4-3
- #94 Romello Height
- #47 Khalid Kareem
- #91 Sam Okuayinonu
- #55 Sebastian Valdez
- #99 C.J. West
- #93 Gracen Halton
- James Thompson Jr.
- #95 Alfred Collins
- #98 Mykel Williams
- #50 Andrew Farmer II
- #49 Garret Wallow
- #48 Tatum Bethune
- #45 Nick Martin
- #51 Luke Gifford
- #6 Malik Mustapha
- #33 Siran Neal Q
- #24 Ashtyn Davis
- #29 Darrick Forrest
- #28 Ephesians Prysock
- #22 Nate Hobbs Q
- #16 Sam Howell
- #32 Tyler Goodson
- #20 Malik Davis
- #9 KaVontae Turpin O
- #81 Jordan Hudson
- #18 Jonathan Mingo
- #80 Camden Brown
- #89 Brevyn Spann-Ford
- #86 Luke Schoonmaker Q
- #84 James Mitchell
- #67 Drew Shelton
- #66 T.J. Bass
- #72 Matt Hennessy
- #65 Ajani Cornelius
- #77 Broderick Jones
Cowboys offense · 11 personnel
San Francisco 49ers depth chart → Dallas Cowboys depth chart →
49ers vs Cowboys injury report
This game's injury reports are not out yet. The depth charts below carry each team's latest report.
San Francisco 49ers depth chart → Dallas Cowboys depth chart →
Frequently asked questions
What time is 49ers vs Cowboys?
Kickoff is Sunday, November 15, 2026 at 4:25 PM ET at AT&T Stadium.
What is the spread for 49ers vs Cowboys?
The median spread across 15 sportsbooks is 49ers -4.5 as of Mon, Nov 9 · 12:52 AM ET. Best available by side: 49ers -4 (-108, BetMGM) · Cowboys +4.5 (-105, Tipico).
What is the over/under for 49ers vs Cowboys?
The median total across 15 sportsbooks is 55.5. Best available: Over 55 (-110, Bally Bet) · Under 56.5 (-110, Hard Rock Bet).
What are the moneyline odds for 49ers vs Cowboys?
The best available moneylines are 49ers (-210, Circa) · Cowboys (+185, DraftKings).
Does KarmaEdge have an AI prediction for 49ers vs Cowboys?
Not yet. No KarmaEdge AI projection is published for 49ers vs Cowboys; games appear once the model is published for the slate. Nothing is filled in meanwhile.
Is KarmaEdge.AI a sportsbook?
No. KarmaEdge.AI is not a sportsbook and never accepts wagers. It is a research site that compares markets and shows KarmaEdge AI research next to them.
KarmaEdge.AI is not a sportsbook and never accepts wagers. Lines move; each shows when it was read. Projections are research, not guarantees. 18+ and of legal age where you are. Gambling problem? Call 1-800-GAMBLER.
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